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Origin and Detection of Neonatal Seizures: Animal and Clinical Studies

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Prenatal and Postnatal Determinants of Development

Part of the book series: Neuromethods ((NM,volume 109))

Abstract

Neonatal seizures remain a major clinical problem worldwide and are harmful to the developing brain. Seizures are associated with poor neurodevelopmental outcomes and significant risk of death requiring urgent diagnosis and intervention. Current antiepileptic drugs however have limited efficacy and are potentially harmful to the developing newborn brain. Despite this, standard clinical practice for the treatment of neonatal seizures remains unchanged. This chapter describes a clinically relevant neonatal animal model of HI-induced seizures.

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Acknowledgments

This work was supported by the National Health and Medical Research Council and The Lions Medical Research Foundation.

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Authors and Affiliations

  1. Perinatal Research Centre, UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD, 4029, Australia

    S. Tracey Bjorkman

Authors
  1. S. Tracey Bjorkman
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Corresponding author

Correspondence to S. Tracey Bjorkman .

Editor information

Editors and Affiliations

  1. Hudson Institute of Medical Research, Monash Medical Centre, The Ritchie Centre, Melbourne, Australia

    David W. Walker

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Bjorkman, S.T. (2016). Origin and Detection of Neonatal Seizures: Animal and Clinical Studies. In: Walker, D. (eds) Prenatal and Postnatal Determinants of Development. Neuromethods, vol 109. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3014-2_17

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  • DOI: https://doi.org/10.1007/978-1-4939-3014-2_17

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-3013-5

  • Online ISBN: 978-1-4939-3014-2

  • eBook Packages: Springer Protocols

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