Abstract
In tissue engineering research, cell-based assays are widely utilized to fundamentally explore cellular responses to extracellular conditions. Nevertheless, the simplified cell culture models available at present have several inherent shortcomings and limitations. To tackle the issues, a wide variety of microbioreactors for cell culture have been actively proposed, especially during the past decade. Among these, micro-scale cell culture devices based on microfluidic biochip technology have particularly attracted considerable attention. In this chapter, we not only discuss the advantageous features of using micro-scale cell culture devices for cell-based assays, but also describe their fabrication, experimental setup, and application.
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Acknowledgement
This work is sponsored by the National Science Council (NSC) in Taiwan (NSC 102-2911-I-182-502), and Chang Gung Memorial Hospital (CMRPD 1C0121).
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Chang, YH., Wu, MH. (2015). Microbioreactors for Cartilage Tissue Engineering. In: Doran, P. (eds) Cartilage Tissue Engineering. Methods in Molecular Biology, vol 1340. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2938-2_17
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DOI: https://doi.org/10.1007/978-1-4939-2938-2_17
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-2937-5
Online ISBN: 978-1-4939-2938-2
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