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Noninvasive Molecular Imaging of Mouse Atherosclerosis

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Book cover Methods in Mouse Atherosclerosis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1339))

Abstract

Molecular imaging offers great potential for noninvasive visualization and quantitation of the cellular and molecular components involved in atherosclerotic plaque stability. In this chapter, we review emerging molecular imaging modalities and approaches for quantitative, noninvasive detection of early biological processes in atherogenesis, including vascular endothelial permeability, endothelial adhesion molecule up-regulation, and macrophage accumulation, with special emphasis on mouse models. We also highlight a number of targeted imaging nanomaterials for assessment of advanced atherosclerotic plaques, including extracellular matrix degradation, proteolytic enzyme activity, and activated platelets using mouse models of atherosclerosis. The potential for clinical translation of molecular imaging nanomaterials for assessment of atherosclerotic plaque biology, together with multimodal approaches is also discussed.

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Author information

Authors and Affiliations

  1. Midatech Ltd., Begbroke Science Park, Begbroke Hill, Woodstock Road, Oxfordshire, OX5 1PF, UK

    Martina A. McAteer

  2. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK

    Robin P. Choudhury

Authors
  1. Martina A. McAteer
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  2. Robin P. Choudhury
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Corresponding author

Correspondence to Martina A. McAteer .

Editor information

Editors and Affiliations

  1. Laboratory of Molecular and Genetic Cardiovascular Pathophysiology, Centro Nacional de Investigaciones Cardiovascular Carlos III (CNIC), Madrid, Madrid, Spain

    Vicente Andrés

  2. Laboratory of Molecular and Genetic Cardiovascular Pathophysiology, Centro Nacional de Investigaciones Cardiovascular Carlos III (CNIC), Madrid, Madrid, Spain

    Beatriz Dorado

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McAteer, M.A., Choudhury, R.P. (2015). Noninvasive Molecular Imaging of Mouse Atherosclerosis. In: Andrés, V., Dorado, B. (eds) Methods in Mouse Atherosclerosis. Methods in Molecular Biology, vol 1339. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2929-0_4

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  • DOI: https://doi.org/10.1007/978-1-4939-2929-0_4

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-2928-3

  • Online ISBN: 978-1-4939-2929-0

  • eBook Packages: Springer Protocols

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