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Use of Mouse Models in Atherosclerosis Research

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Methods in Mouse Atherosclerosis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1339))

Abstract

Cardiovascular disease is the major cause of death in most developed nations and the social and economic burden of this disease is quite high. Atherosclerosis is a major underlying basis for most cardiovascular diseases including myocardial infarction and stroke. Genetically modified mouse models, particularly mice deficient in apoprotein E or the LDL receptor, have been widely used in preclinical atherosclerosis studies to gain insight into the mechanisms underlying this pathology. This chapter reviews several mouse models of atherosclerosis progression and regression as well as the role of immune cells in disease progression and the genetics of murine atherogenesis.

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Authors and Affiliations

  1. Department of Pathology, University of Chicago, Box MC 1089, 5841 S. Maryland Avenue, Chicago, IL, 60637, USA

    Godfrey S. Getz & Catherine A. Reardon

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  1. Godfrey S. Getz
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  2. Catherine A. Reardon
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Correspondence to Godfrey S. Getz .

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Editors and Affiliations

  1. Laboratory of Molecular and Genetic Cardiovascular Pathophysiology, Centro Nacional de Investigaciones Cardiovascular Carlos III (CNIC), Madrid, Madrid, Spain

    Vicente Andrés

  2. Laboratory of Molecular and Genetic Cardiovascular Pathophysiology, Centro Nacional de Investigaciones Cardiovascular Carlos III (CNIC), Madrid, Madrid, Spain

    Beatriz Dorado

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Getz, G.S., Reardon, C.A. (2015). Use of Mouse Models in Atherosclerosis Research. In: Andrés, V., Dorado, B. (eds) Methods in Mouse Atherosclerosis. Methods in Molecular Biology, vol 1339. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2929-0_1

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  • DOI: https://doi.org/10.1007/978-1-4939-2929-0_1

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-2928-3

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