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Perinatal Intracerebral Hemorrhage Model and Developmental Disability

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Animal Models of Neurodevelopmental Disorders

Part of the book series: Neuromethods ((NM,volume 104))

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Abstract

Perinatal intracerebral hemorrhage, also known as germinal matrix hemorrhage (GMH), refers to the bleeding that arises from the sub-ependymal (or periventricular) germinal region of the immature brain. Intraventricular hemorrhage (IVH) refers to the bleeding that extends into the ventricles, usually as an extension of GMH. Clinical studies have shown that infants who experience GMH/IVH may develop hydrocephalus or suffer from long-term neurological dysfunctions, including cerebral palsy, seizures, and learning disabilities. Understanding the pathogenesis of subsequent brain damage is important for the prevention and management of GMH/IVH. Appropriate animal models are necessary to achieve this understanding. Rodent models of GMH/IVH are economical, homogenous within a strain, and suitable for studying some long-term outcomes. This chapter reviews rodent models of GMH/IVH and their neurobehavioral outcomes.

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Authors and Affiliations

  1. Division of Pediatric Neurology, University of Alberta Hospital, Edmonton, AB, Canada

    Janani Kassiri

  2. Department of Pathology, College of Medicine, Faculty of Health Sciences, University of Manitoba, Room 401 Brodie Centre, 727 McDermot Avenue, Winnipeg, MB, Canada, R3E 3P5

    Marc Del Bigio M.D., Ph.D., F.R.C.P.C.

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  1. Janani Kassiri
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Correspondence to Marc Del Bigio M.D., Ph.D., F.R.C.P.C. .

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Editors and Affiliations

  1. Div. Pediatric Neurology, University of Alberta Dept. Pediatrics, Edmonton, Alberta, Canada

    Jerome Y. Yager

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Kassiri, J., Del Bigio, M. (2015). Perinatal Intracerebral Hemorrhage Model and Developmental Disability. In: Yager, J. (eds) Animal Models of Neurodevelopmental Disorders. Neuromethods, vol 104. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2709-8_3

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  • DOI: https://doi.org/10.1007/978-1-4939-2709-8_3

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-2708-1

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