Abstract
Intra-ventricular hemorrhage (IVH) and post-hemorrhagic ventricular dilatation (PHVD) are important issues in neonatal care and continue to contribute to significant motor and cognitive morbidity. Several questions about its pathophysiology remain unanswered and animal models have been useful in identifying relevant risk factors and potential mechanisms. In this chapter, we describe a neonatal piglet model of IVH and PHVD involving the injection of homologous blood with an elevated hematocrit into the ventricular system. The animals are capable of long-term survival and, through a ventricular access device inserted in the second week, allow repeated aspiration of cerebrospinal fluid and measurement of intraventricular pressure.
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Aquilina, K., Thoresen, M. (2015). A Newborn Piglet Survival Model of Post-hemorrhagic Ventricular Dilatation (PHVD). In: Yager, J. (eds) Animal Models of Neurodevelopmental Disorders. Neuromethods, vol 104. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2709-8_10
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DOI: https://doi.org/10.1007/978-1-4939-2709-8_10
Publisher Name: Humana Press, New York, NY
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