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Unilateral Common Carotid Artery Ligation as a Model of Perinatal Asphyxia: The Original Rice–Vannucci Model

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Animal Models of Neurodevelopmental Disorders

Part of the book series: Neuromethods ((NM,volume 104))

Abstract

Hypoxic-ischemic encephalopathy (HIE) is a detrimental event leading to unfavorable neurological outcomes in the newborn, the clinical phenotype of which is typically referred to as cerebral palsy. The high incidence of HIE results in a need for animal models that can replicate this human experience in order to determine the pathophysiology of injury and develop therapeutic interventions. One of the first models to be developed was, the now commonly referred to as the Rice–Vannucci model, after the student and principle investigator who first developed and described the model. Now, perhaps the best characterized and certainly the most commonly utilized model to reflect perinatal hypoxic-ischemic injury, the “Rice–Vannucci” model is the cornerstone to investigating neonatal brain injury and hypoxic-ischemic encephalopathy. This chapter describes the methodology for utilizing this model, attempt to recognize aspects of the model which have since evolved since its inception, and identify areas of caution when undertaking its use for hypoxic-ischemic encephalopathy.

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Author information

Authors and Affiliations

  1. Department of Pediatrics, University of Alberta, 116 St and 85AV, Edmonton, AB, Canada, T6G 1C9

    Antoinette Nguyen & Edward A. Armstrong

  2. Division of Pediatric Neurology, Department of Pediatrics, University of Alberta, 116 St and 85AV, Edmonton, AB, Canada, T6G 1C9

    Jerome Y. Yager M.D.

Authors
  1. Antoinette Nguyen
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  2. Edward A. Armstrong
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  3. Jerome Y. Yager M.D.
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Corresponding author

Correspondence to Jerome Y. Yager M.D. .

Editor information

Editors and Affiliations

  1. Div. Pediatric Neurology, University of Alberta Dept. Pediatrics, Edmonton, Alberta, Canada

    Jerome Y. Yager

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Nguyen, A., Armstrong, E.A., Yager, J.Y. (2015). Unilateral Common Carotid Artery Ligation as a Model of Perinatal Asphyxia: The Original Rice–Vannucci Model. In: Yager, J. (eds) Animal Models of Neurodevelopmental Disorders. Neuromethods, vol 104. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2709-8_1

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  • DOI: https://doi.org/10.1007/978-1-4939-2709-8_1

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-2708-1

  • Online ISBN: 978-1-4939-2709-8

  • eBook Packages: Springer Protocols

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