Abstract
We have developed cell fusion vaccines generated with dendritic cells (DCs) and whole tumor cells to induce antigen-specific antitumor immunity. This approach allows DCs to be exposed to the entire repertoire of tumor-associated antigens (TAAs) originally expressed by the tumor cell, to process them endogenously, and to present antigenic epitopes thought the MHC class I and class II pathways to activate both CD8+ and CD4+ T cells, respectively. The therapeutic efficacy of DC/tumor fusion cell vaccines requires the improved immunogenicity of both cells. Here, we describe the strategy to generate DC/tumor fusion cells.
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Koido, S., Gong, J. (2015). Cell Fusion Between Dendritic Cells and Whole Tumor Cells. In: Pfannkuche, K. (eds) Cell Fusion. Methods in Molecular Biology, vol 1313. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2703-6_13
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DOI: https://doi.org/10.1007/978-1-4939-2703-6_13
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-2702-9
Online ISBN: 978-1-4939-2703-6
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