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Cardiomyocytes pp 51–64Cite as

Next-Generation Sequencing Technology in the Genetics of Cardiovascular Disease

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1299))

Abstract

In recent years, next-generation sequencing (NGS) technologies have revolutionized approaches to genetic studies, making whole-genome sequencing a possible way for obtaining global genomic information. At present, three most NGS platforms are used in genetics for clonally amplified templates. These technologies share general processing steps but differing in specific technical details that determine their limits or advantages. NGS has been recently shown to have great potential for identifying novel causative mutations in different disorders. It is expected that the NGS will be increasingly important in the study of inherited and complex traits such as cardiovascular diseases (CVDs). Indeed, the identification and characterization of genes that enhance prediction of CVDs risk remain an important challenge for improving prevention and treatment.

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Acknowledgements

This research was partially funded by a grant from Italian Ministry of Research’s Fund for Basic Research (FIRB 2005).

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Authors and Affiliations

  1. Institute of Clinical Physiology-CNR, Via Moruzzi 1, 56124, Pisa, Italy

    Cecilia Vecoli

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  1. Cecilia Vecoli
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Corresponding author

Correspondence to Cecilia Vecoli .

Editor information

Editors and Affiliations

  1. Rochester Institute of Technology, Rochester, New York, USA

    Gary R. Skuse

  2. Rochester Institute of Technology, Rochester, New York, USA

    Maureen C. Ferran

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Vecoli, C. (2015). Next-Generation Sequencing Technology in the Genetics of Cardiovascular Disease. In: Skuse, G., Ferran, M. (eds) Cardiomyocytes. Methods in Molecular Biology, vol 1299. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2572-8_4

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  • DOI: https://doi.org/10.1007/978-1-4939-2572-8_4

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-2571-1

  • Online ISBN: 978-1-4939-2572-8

  • eBook Packages: Springer Protocols

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