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Lung Adenocarcinomas: Comparison Between Mice and Men

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Mouse Models of Cancer

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1267))

Abstract

A few human tumor types have been modeled in mice using genetic or chemical tools. The final goal of these efforts is to establish models that mimic not only the location and cellular origin of human cancers but also their genetic aberrations and morphologic appearances. The latter has been neglected by most investigators, and comparative histopathology of human versus mouse cancers is not readily available. This issue is exacerbated by the fact that some human malignancies comprise a whole spectrum of cancer subtypes that differ molecularly and morphologically. Lung cancer is a paradigm that appears not only as non-small cell and small-cell lung cancer but comprises a plethora of subtypes with distinct morphologic features. This review discusses species-specific and common morphological features of non-small cell lung cancer in mice and humans. Potential inconsistencies and the need for refined genetic tools are discussed in the context of a comparative analysis between commonly employed RAS-induced mouse tumors and human lung cancers.

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Acknowledgements

I am grateful to Dr. Loupal (University of Veterinary Medicine, Dept. Pathology, Vienna, Austria) for providing diseased lung tissues from different animal species for the study of lung architecture as well as variations of diseases in animal lungs compared to human lungs. I am also grateful to Josef Penninger for enabling the studies on KRAS-induced mouse adenocarcinomas and to Rao Shuan, Sara Soto, and Beatrice Grabner for sharing their slides with me.

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  1. Institute of Pathology, Research Unit Molecular Lung & Pleura Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036, Graz, Austria

    Helmut H. Popper

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Correspondence to Helmut H. Popper .

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  1. Medical University Vienna (MUV) Institute for Cancer Research, Vienna, Austria

    Robert Eferl

  2. Research (LBI-CR), Medical University Vienna (MUV), Center of Physiology and Pharmacology & Ludwig Boltzmann Institute for Cancer, Vienna, Austria

    Emilio Casanova

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Popper, H.H. (2015). Lung Adenocarcinomas: Comparison Between Mice and Men. In: Eferl, R., Casanova, E. (eds) Mouse Models of Cancer. Methods in Molecular Biology, vol 1267. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2297-0_2

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  • DOI: https://doi.org/10.1007/978-1-4939-2297-0_2

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