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Applied Neurogenomics pp 1–59Cite as

An Overview of Methods Used in Neurogenomics and Their Applications

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Part of the book series: Neuromethods ((NM,volume 97))

Abstract

This chapter is an introduction to and an overview of neurogenomics—an analysis of genes in the nervous system and their application for diagnosis as well as potential therapeutics of disorders of the nervous system. The most important technologies are those for sequencing. Traditional as well as new techniques are described briefly including next-generation sequencing. Important applications include discovery of genomic biomarkers, brain mapping as well as connectomics, molecular diagnostics, drug discovery, and potential new therapeutics for neurologic disorders. Knowledge of the genes relevant to the nervous system will improve gene therapies and RNA interference approaches for neurologic disorders. Overall it will contribute to development of personalized neurology.

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Abbreviations

NGS:

Next-generation sequencing

WGS:

Whole-genome sequencing

WES:

Whole-exome sequencing

CNV:

Copy number variation

SNP:

Single-nucleotide polymorphism

SMS:

Single-molecule sequencing

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  1. Jain PharmaBiotech, Blaesiring 7, CH-4057, Basel, Switzerland

    Kewal K. Jain M.D., F.R.A.C.S., F.F.P.M.

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Correspondence to Kewal K. Jain M.D., F.R.A.C.S., F.F.P.M. .

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    Kewal K. Jain

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Jain, K.K. (2015). An Overview of Methods Used in Neurogenomics and Their Applications. In: Jain, K. (eds) Applied Neurogenomics. Neuromethods, vol 97. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2247-5_1

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  • DOI: https://doi.org/10.1007/978-1-4939-2247-5_1

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