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Bone Marrow Transplantation for Research and Regenerative Therapies in the Central Nervous System

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Neuronal Cell Death

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1254))

Abstract

Bone marrow stem cells are probably the best known stem cell type and have been employed for more than 50 years, especially in pathologies related to the hematopoietic and immune systems. However, their potential for therapeutic application is much broader (because these cells can differentiate into hepatocytes , myocytes , cardiomyocytes , pneumocytes or neural cells , among others), and they can also presumably be employed to palliate neural diseases . Current research addressing the integration of bone marrow -derived cells in the neural circuits of the central nervous system together with their features and applications are hotspots in current Neurobiology. Nevertheless, as in other leading research lines the efficacy and possibilities of their therapeutic application depend on the technical procedures employed, which are still far from being standardized. In this chapter we shall explain one of these procedures in depth, namely the transplantation of whole bone marrow from harvested bone marrow stem cells for subsequent integration into the encephalon .

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Acknowledgements

This work was supported by the Ministerio de Investigación y Ciencia (BFU2010-18284), Junta de Castilla y León and Centre for Regenerative Medicine and Cell Therapy of Castilla y León. The authors also express their gratitude to N. Skinner for revising the English version of the manuscript.

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Authors and Affiliations

  1. Laboratory of Neuronal Plasticity and Neurorepair, Institute for Neuroscience of Castilla y León (INCyL), Universidad de Salamanca, C/ Pintor Fernando Gallego 1, Salamanca, E-37007, Spain

    David Díaz, José Ramón Alonso & Eduardo Weruaga

  2. IBSAL – Institute of Biomedical Research of Salamanca, Universidad de Salamanca, Salamanca, Spain

    David Díaz, José Ramón Alonso & Eduardo Weruaga

  3. Instituto de Alta Investigación, Universidad de Tarapacá, Arica, Chile

    José Ramón Alonso

Authors
  1. David Díaz
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  2. José Ramón Alonso
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  3. Eduardo Weruaga
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Corresponding author

Correspondence to José Ramón Alonso .

Editor information

Editors and Affiliations

  1. Dept. of Veterinary Sciences, University of Torino, Grugliasco, Torino, Italy

    Laura Lossi

  2. Dept. of Veterinary Sciences, University of Torino, Grugliasco, Torino, Italy

    Adalberto Merighi

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Díaz, D., Alonso, J.R., Weruaga, E. (2015). Bone Marrow Transplantation for Research and Regenerative Therapies in the Central Nervous System. In: Lossi, L., Merighi, A. (eds) Neuronal Cell Death. Methods in Molecular Biology, vol 1254. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2152-2_22

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  • DOI: https://doi.org/10.1007/978-1-4939-2152-2_22

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-2151-5

  • Online ISBN: 978-1-4939-2152-2

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