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Feedback Loops in Biological Networks

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Computational Methods in Synthetic Biology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1244))

Abstract

We introduce fundamental concepts for the design of dynamics and feedback in molecular networks modeled with ordinary differential equations. We use several examples, focusing in particular on the mitogen-activated protein kinase (MAPK) pathway, to illustrate the concept that feedback loops are fundamental in determining the overall dynamic behavior of a system. Often, these loops have a structural function and unequivocally define the system behavior. We conclude with numerical simulations highlighting the potential for bistability and oscillations of the MAPK pathway re-engineered through synthetic promoters and RNA transducers to include positive and negative feedback loops.

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Author information

Authors and Affiliations

  1. Department of Mechanical Engineering, University of California at Riverside, Riverside, CA, 92521, USA

    Elisa Franco

  2. Department of Stem Cell Biology and Regenerative Medicine at the Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA

    Kate E. Galloway

Authors
  1. Elisa Franco
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  2. Kate E. Galloway
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Corresponding author

Correspondence to Elisa Franco .

Editor information

Editors and Affiliations

  1. School of Life Science and Technology, Harbin Institute of Technology, Harbin, China

    Mario Andrea Marchisio

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Franco, E., Galloway, K.E. (2015). Feedback Loops in Biological Networks. In: Marchisio, M. (eds) Computational Methods in Synthetic Biology. Methods in Molecular Biology, vol 1244. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1878-2_10

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  • DOI: https://doi.org/10.1007/978-1-4939-1878-2_10

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1877-5

  • Online ISBN: 978-1-4939-1878-2

  • eBook Packages: Springer Protocols

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