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Cancer Epigenetics pp 523–538Cite as

Detection of Circulatory MicroRNAs in Prostate Cancer

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1238))

Abstract

Prostate cancer (PCa) is one of the most common cancer worldwide and accounts for 14.4 % of all new cancer cases. The clinical outcome and management of PCa can be significantly improved by use of biomarker assays for early detection, prognosis and also for prediction and monitoring of treatment response. MiRNAs are short, endogenous, single-stranded RNA molecules that play important role in regulation of gene expression and can modulate a number of cellular processes. Discovery of miRNAs in circulation has not only facilitated understanding their role in various diseases but also paved new avenues for biomarker discovery due to their ease of access and stability. The fact that a minimally invasive test based on miRNAs profiles can distinguish the presence or absence of disease illustrates immense potential of these molecules as predictive biomarkers.

In this chapter, we have summarized the presumed mechanisms of miRNA release into the circulation and systematically summarized the studies of circulatory miRNAs in PCa. Also, we have mainly focused on the methodology of identification of circulatory miRNAs from biofluids.

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Author information

Authors and Affiliations

  1. Department of Biology, Chemistry and Physics, Cancer Research Laboratory, University of the District of Columbia, Washington DC, 20008, USA

    Anvesha Srivastava, Helle Goldberger, Zainab Afzal & Deepak Kumar Ph.D.

  2. Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, 20057, USA

    Simeng Suy, Sean P. Collins & Deepak Kumar Ph.D.

  3. Department of Biological and Environmental Sciences, University of the District of Columbia, Building 44, Room 312, 4200 Connecticut Avenue, NW, Washington DC, 20008, USA

    Deepak Kumar Ph.D.

Authors
  1. Anvesha Srivastava
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  2. Helle Goldberger
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  3. Zainab Afzal
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  4. Simeng Suy
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  5. Sean P. Collins
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  6. Deepak Kumar Ph.D.
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Corresponding author

Correspondence to Deepak Kumar Ph.D. .

Editor information

Editors and Affiliations

  1. National Institutes of Health, Rockville, Maryland, USA

    Mukesh Verma

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© 2015 Springer Science+Business Media New York

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Srivastava, A., Goldberger, H., Afzal, Z., Suy, S., Collins, S.P., Kumar, D. (2015). Detection of Circulatory MicroRNAs in Prostate Cancer. In: Verma, M. (eds) Cancer Epigenetics. Methods in Molecular Biology, vol 1238. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1804-1_27

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  • DOI: https://doi.org/10.1007/978-1-4939-1804-1_27

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1803-4

  • Online ISBN: 978-1-4939-1804-1

  • eBook Packages: Springer Protocols

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