Sepsis pp 241-246 | Cite as

Host Response Biomarker in Sepsis: suPAR Detection

  • Evangelos J. Giamarellos-BourboulisEmail author
  • Marianna Georgitsi
Part of the Methods in Molecular Biology book series (MIMB, volume 1237)


Recent studies of our group have shown that suPAR may complement APACHE II score for risk assessment in sepsis. suPAR may be measured in serum of patients by an enzyme immunosorbent assay developed by Virogates (suPARnostic™). Production of suPAR from circulating neutrophils and monocytes may be assessed after isolation of neutrophils and monocytes and ex vivo culture. This is followed by measurement of suPAR in culture supernatants.

Key words

suPAR Sepsis Neutrophils Severity Immunoassay 


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Evangelos J. Giamarellos-Bourboulis
    • 1
    • 2
    Email author
  • Marianna Georgitsi
    • 1
  1. 1.4th Department of Internal MedicineUniversity of Athens, Medical SchoolAthensGreece
  2. 2.4th Department of Internal MedicineAttikon University HospitalAthensGreece

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