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Sepsis pp 225-239 | Cite as

Host Response Biomarkers in Sepsis: Overview on sTREM-1 Detection

  • Jérémie Lemarié
  • Damien Barraud
  • Sébastien GibotEmail author
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1237)

Abstract

The diagnosis of sepsis, and especially its differentiation from sterile inflammation, may be challenging. TREM-1, the triggering receptor expressed on myeloid cells-1, is an amplifier of the innate immune response. Its soluble form acts as a decoy for the natural TREM-1 ligand and dampens its activation. In this chapter, we review the numerous studies that have evaluated the usefulness of sTREM-1 concentration determination for the diagnosis and the prognosis evaluation of sepsis or localized infection. Nowadays, sandwich ELISA kits are available and the assay is described.

Key words

Sepsis Diagnostic Biomarkers sTREM-1 SIRS Sandwich ELISA 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Jérémie Lemarié
    • 1
  • Damien Barraud
    • 1
  • Sébastien Gibot
    • 1
    Email author
  1. 1.Department of Medical Intensive CareHôpital CentralNancy CedexFrance

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