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The Function of Mast Cells in Autoimmune Glomerulonephritis

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Mast Cells

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1220))

Abstract

Immune-mediated glomerulonephritis is caused by deposition of immune complexes on the glomerular basement membrane or of autoantibodies directed against the glomerular basement membrane. Depositions lead to an inflammatory response that can ultimately destroy renal function and lead to chronic kidney disease. However, the pathological processes leading to the development of renal injury and disease progression remain poorly understood. To investigate the mechanisms of disease development in glomerulonephritis various animal models have been developed, which include as the most popular one the induction of glomerulonephritis by the injection of heterologous antibodies directed to the glomerular basement membrane. The role of mast cells and mast cell-derived mediators has been evaluated in these models. In this chapter we describe the methods that allow to set up and study the disease parameters of immune-mediated glomerulonephritis development.

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Authors and Affiliations

  1. Inserm UMRS-699, Paris, 75018, France

    Renato C. Monteiro, Walid Beghdadi, Lydia Celia Madjene, Maguelonne Pons & Ulrich Blank

  2. Sorbonne Paris Cite, Paris, 75018, France

    Renato C. Monteiro, Walid Beghdadi, Lydia Celia Madjene, Maguelonne Pons, Michel Peuchmaur & Ulrich Blank

  3. Faculté de Médecine site X. Bichat, Inserm U699, Université Paris-Diderot, 16 rtue Henri Huchard, Paris 7, Paris, 75018, France

    Renato C. Monteiro & Ulrich Blank

  4. APHP, Hôpital Robert Debré, Service de Pathologie, Paris, France

    Michel Peuchmaur

Authors
  1. Renato C. Monteiro
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  2. Walid Beghdadi
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  3. Lydia Celia Madjene
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  4. Maguelonne Pons
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  5. Michel Peuchmaur
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  6. Ulrich Blank
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Corresponding author

Correspondence to Ulrich Blank .

Editor information

Editors and Affiliations

  1. Department of Medical Genetics, The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada

    Michael R. Hughes

  2. Department of Medical Genetics, The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada

    Kelly M. McNagny

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© 2015 Springer Science+Business Media New York

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Monteiro, R.C., Beghdadi, W., Madjene, L.C., Pons, M., Peuchmaur, M., Blank, U. (2015). The Function of Mast Cells in Autoimmune Glomerulonephritis. In: Hughes, M., McNagny, K. (eds) Mast Cells. Methods in Molecular Biology, vol 1220. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1568-2_29

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  • DOI: https://doi.org/10.1007/978-1-4939-1568-2_29

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1567-5

  • Online ISBN: 978-1-4939-1568-2

  • eBook Packages: Springer Protocols

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