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Molecular Modeling of Proteins pp 331–350Cite as

De Novo Membrane Protein Structure Prediction

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1215))

Abstract

Recent advances in identifying residue–residue contacts from large multiple sequence alignments have enabled impressive gains to be made in the field of protein structure prediction. In this chapter, we discuss these advances and provide a step-by-step guide to applying the latest tools to the de novo modelling of alpha-helical transmembrane proteins. As a practical example, we demonstrate the process of building an accurate 3D model of a G protein-coupled receptor, correctly orientated in the membrane, using only its primary protein sequence.

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Author information

Authors and Affiliations

  1. Bioinformatics Group, Department of Computer Science, University College London, Office: 8.11, Desk: 206, Gower Street, London, WC1E 6BT, UK

    Timothy Nugent

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  1. Timothy Nugent
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Correspondence to Timothy Nugent .

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Editors and Affiliations

  1. University of Hertfordshire, Hatfield, Hertfordshire, United Kingdom

    Andreas Kukol

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Nugent, T. (2015). De Novo Membrane Protein Structure Prediction. In: Kukol, A. (eds) Molecular Modeling of Proteins. Methods in Molecular Biology, vol 1215. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1465-4_15

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  • DOI: https://doi.org/10.1007/978-1-4939-1465-4_15

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1464-7

  • Online ISBN: 978-1-4939-1465-4

  • eBook Packages: Springer Protocols

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