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Animal Models for Stem Cell Therapy pp 331–339Cite as

Therapeutic Application of Mesenchymal Stromal Cells in Murine Models of Inflammatory Bowel Disease

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1213))

Abstract

Mesenchymal stromal cells (MSCs) are currently under investigation for the treatment of inflammatory bowel disease (IBD), including Crohn’s disease. The models of colitis induced by intrarectal infusion of 2,4,6-trinitrobenzene sulfonic acid (TNBS) or by oral administration of dextran sulfate sodium (DSS) in susceptible mouse strains have been commonly used as preclinical tools to demonstrate the efficiency of treatments with MSCs isolated from various sources. Both models are being and will be critical to improve MSC-based therapies in human IBD by assaying new pathways, therapeutic regimes and tissue targeting strategies. Here, we describe our experiences in the treatment of acute and chronic TNBS- and DSS-induced colitis with MSCs.

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Author information

Authors and Affiliations

  1. Institute of Parasitology and Biomedicine “Lopez-Neyra”, CSIC, Avenida del Conocimiento s/n, 18016, Granada, Spain

    Elena Gonzalez-Rey & Mario Delgado

Authors
  1. Elena Gonzalez-Rey
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  2. Mario Delgado
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Corresponding author

Correspondence to Mario Delgado .

Editor information

Editors and Affiliations

  1. Department of Surgery, Unviersity of Leipzig, Germany

    Bruno Christ

  2. Department of Surgery, University of Leipzig, Germany

    Jana Oerlecke

  3. Department of Surgery, University of Leipzig, Germany

    Peggy Stock

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© 2014 Springer Science+Business Media New York

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Gonzalez-Rey, E., Delgado, M. (2014). Therapeutic Application of Mesenchymal Stromal Cells in Murine Models of Inflammatory Bowel Disease. In: Christ, B., Oerlecke, J., Stock, P. (eds) Animal Models for Stem Cell Therapy. Methods in Molecular Biology, vol 1213. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1453-1_27

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  • DOI: https://doi.org/10.1007/978-1-4939-1453-1_27

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1452-4

  • Online ISBN: 978-1-4939-1453-1

  • eBook Packages: Springer Protocols

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