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A Toolkit for Clinical Statisticians to Fix Problems Based on Biomarker Measurements Subject to Instrumental Limitations: From Repeated Measurement Techniques to a Hybrid Pooled–Unpooled Design

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Advanced Protocols in Oxidative Stress III

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1208))

Abstract

The aim of this chapter is to review and examine different methods in order to display correct and efficient statistical techniques based on complete/incomplete data subject to different sorts of measurement error (ME) problems. Instrument inaccuracies, biological variations, and/or errors in questionnaire-based self-report data can lead to significant MEs in various clinical experiments. Ignoring MEs can cause bias or inconsistency of statistical inferences. The biostatistical literature well addresses two categories of MEs: errors related to additive models and errors caused by the limit of detection (LOD). Several statistical approaches have been developed to analyze data affected by MEs, including the parametric/nonparametric likelihood methodologies, Bayesian methods, the single and multiple imputation techniques, and the repeated measurement design of experiment. We present a novel hybrid pooled–unpooled design as one of the strategies to provide correct statistical inferences when data is subject to MEs. This hybrid design and the classical techniques are compared to show the advantages and disadvantages of the considered methods.

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Author information

Authors and Affiliations

  1. Department of Biostatistics, New York State University at Buffalo, 715 Kimball Tower, 3435 Main Street, Buffalo, NY, 14214, USA

    Albert Vexler, Ge Tao & Xiwei Chen

Authors
  1. Albert Vexler
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  2. Ge Tao
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  3. Xiwei Chen
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Corresponding author

Correspondence to Albert Vexler .

Editor information

Editors and Affiliations

  1. University of Florida, Gainsville, Florida, USA

    Donald Armstrong

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Vexler, A., Tao, G., Chen, X. (2015). A Toolkit for Clinical Statisticians to Fix Problems Based on Biomarker Measurements Subject to Instrumental Limitations: From Repeated Measurement Techniques to a Hybrid Pooled–Unpooled Design. In: Armstrong, D. (eds) Advanced Protocols in Oxidative Stress III. Methods in Molecular Biology, vol 1208. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1441-8_31

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  • DOI: https://doi.org/10.1007/978-1-4939-1441-8_31

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1440-1

  • Online ISBN: 978-1-4939-1441-8

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