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Advanced Protocols in Oxidative Stress III pp 313–327Cite as

Substituted Pyridoindoles as Biological Antioxidants: Drug Design, Chemical Synthesis, and Biological Activity

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1208))

Abstract

Great effort has been devoted to design and synthesize biologically active and pharmacologically acceptable antioxidants. Although a number of efficient antioxidant compounds have been designed, synthesized, and tested in animals, none of them have demonstrated sufficient efficacy in human clinical trials without undesirable side effects. Thus new pharmacologically applicable antioxidants have been sought for. Substituted pyridoindoles represent a broad spectrum of pharmacologically active substances including highly effective scavengers of reactive oxygen species. The hexahydropyridoindole scaffold represents a valuable lead with a great deal of knowledge on molecular mechanisms of free radical scavenging, on bioavailability and toxicity. Its modification may yield congeners tailored according to specific requirements for antiradical efficacy, lipophilicity, and basicity, meeting the aim of providing a pharmacologically practicable antioxidant drug as exemplified by the novel derivative SMe1EC2.

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Acknowledgments

This study was supported by the grant VEGA 2/0067/11.

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Authors and Affiliations

  1. Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dubravska cesta 9, 841 04, Bratislava, Slovakia

    Lucia Kovacikova, Magdalena Majekova & Milan Stefek

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  1. Lucia Kovacikova
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  2. Magdalena Majekova
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  3. Milan Stefek
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Correspondence to Milan Stefek .

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  1. University of Florida, Gainsville, Florida, USA

    Donald Armstrong

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Kovacikova, L., Majekova, M., Stefek, M. (2015). Substituted Pyridoindoles as Biological Antioxidants: Drug Design, Chemical Synthesis, and Biological Activity. In: Armstrong, D. (eds) Advanced Protocols in Oxidative Stress III. Methods in Molecular Biology, vol 1208. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1441-8_23

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  • DOI: https://doi.org/10.1007/978-1-4939-1441-8_23

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