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Paxillin and Steroid Signaling: From Frog to Human

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Steroid Receptors

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1204))

Abstract

Paxillin is a well-characterized cytoplasmic adaptor protein that is known to play important roles in cytoskeletal rearrangement, cell adhesion, and cell motility. In addition to its structural functions, paxillin has more recently been shown to function as a regulator of cell division—mediating steroid-triggered meiosis in oocytes as well as steroid- and growth factor-induced proliferation in prostate and breast cancer. Paxillin mediates these processes through a conserved pathway that involves both extranuclear (nongenomic) and nuclear (genomic) steroid signaling, as well as both cytoplasmic and nuclear kinase signaling. In fact, paxillin appears to serve as a critical liaison between extranuclear and nuclear signaling in response to multiple stimuli, making it a fascinating molecule to study when trying to determine how growth signals from the membrane lead to important proliferative changes in the nucleus. This chapter outlines recent advances in understanding how paxillin regulates both steroid and growth factor signaling, focusing on the conserved nature of its actions from a frog germ cell to a human cancer cell.

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave., 693, Rochester, NY, 14642, USA

    Stephen R. Hammes, Susanne U. Miedlich & Aritro Sen

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  1. Stephen R. Hammes
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  2. Susanne U. Miedlich
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  3. Aritro Sen
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Correspondence to Stephen R. Hammes .

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Editors and Affiliations

  1. Second University of Naples, Naples, Italy

    Gabriella Castoria  & Ferdinando Auricchio  & 

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Hammes, S.R., Miedlich, S.U., Sen, A. (2014). Paxillin and Steroid Signaling: From Frog to Human. In: Castoria, G., Auricchio, F. (eds) Steroid Receptors. Methods in Molecular Biology, vol 1204. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-1346-6_9

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  • DOI: https://doi.org/10.1007/978-1-4939-1346-6_9

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-1345-9

  • Online ISBN: 978-1-4939-1346-6

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