Hox Genes pp 121-131 | Cite as

Mining the Cis-Regulatory Elements of Hox Clusters

  • Navneet Kaur Matharu
  • Rakesh K. MishraEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1196)


Hox clusters have served as a favorite system to study the role of cis-regulatory elements at multiple layers of gene regulation. Organization and regulation of Hox genes show remarkable conservation and determine the anterior–posterior body axis across the bilaterians. Identification of a variety of regulatory regions within the complex and around it, embedded primarily in the noncoding part of the corresponding genomic region that can spread 100–150 kb, is a challenging problem. Multiple experimental and computational tools need to be employed to investigate functional features of such elements. Here we discuss parallel approaches to mine the most plausible regulatory information from the noncoding sequences of Hox clusters, among diverse species.

Key words

Hox cluster Cis-regulatory element (CRE) Polycomb response element (PRE) Insulator Chromatin domain boundary CNCS 



Authors acknowledge financial support from Council of Scientific and Industrial Research (CSIR) through network programs BSC0208 and BSC0118.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Centre for Cellular and Molecular BiologyCouncil of Scientific and Industrial ResearchHyderabadIndia

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