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Cross Talk Between the Metabolic and Immune Systems

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Immunoinformatics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1184))

Abstract

Understanding the interplay between metabolic and cellular signaling systems has emerged as a focus in the study of metabolic disorders, cancer, and immune responses. Immune system is active in the regulation of metabolism. Lymphocyte activation initiates a program of cell growth, proliferation, and differentiation that increase metabolic demand. Activated lymphocytes must alter their metabolism to support these increased synthetic activities. In this chapter, we describe how signaling via the immune system integrates with metabolic functions to control immune response and vice versa. It has been explained mainly in the context of T lymphocyte activation and, to a lesser detail, in other immune cell types.

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Acknowledgment

Ms. Namrata Tomar, one of the authors, gratefully acknowledges CSIR, India, for providing her a Senior Research Fellowship (9/93(0145)/12, EMR-I).

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Authors and Affiliations

  1. Machine Intelligence Unit, Indian Statistical Institute, 203 Barrackpore Trunk Road, Kolkata, 700108, India

    Namrata Tomar & Rajat K. De

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  1. Namrata Tomar
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  2. Rajat K. De
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Correspondence to Rajat K. De .

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Editors and Affiliations

  1. Indian Statistical Institute, Kolkata, West Bengal, India

    Rajat K. De

  2. Indian Statistical Institute, Kolkata, West Bengal, India

    Namrata Tomar

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Tomar, N., De, R.K. (2014). Cross Talk Between the Metabolic and Immune Systems. In: De, R., Tomar, N. (eds) Immunoinformatics. Methods in Molecular Biology, vol 1184. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1115-8_2

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  • DOI: https://doi.org/10.1007/978-1-4939-1115-8_2

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1114-1

  • Online ISBN: 978-1-4939-1115-8

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