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The Senescence Arrest Program and the Cell Cycle

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1170))

Abstract

All living organisms are subject to progressive loss of function and damage to their tissues, a process known as aging. At the cellular level, the accumulation of damage to DNA, proteins, and organelles induces cellular senescence, a stress-response pathway that likely influences the aging process. Although the senescence arrest program was initially described in vitro, accumulating evidence suggests that this damage response program occurs in a variety of pathologic settings. This review discusses aspects of the senescence program, their interrelationships with damage arrest pathways, the cell cycle, and the impact of senescence in vivo.

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Acknowledgements

This work was supported in part by NIH grant AG039799 (C.S.).

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Authors and Affiliations

  1. Department of Pathology, Drexel University College of Medicine, 245 N 15th Street, MS 435, Philadelphia, PA, 19092, USA

    Elizabeth P. Crowe, Claudio Torres & Christian Sell

  2. Department of Pathology, University of Washington, Health Science Building D-514, Seattle, 357470, WA, USA

    Alessandro Bitto

  3. Department of Environmental Medicine, Lung Biology, and Disease Program, Pulmonary and Critical Care Division, University of Rochester Medical Center, Rochester, NY, USA

    Chad Lerner

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  1. Alessandro Bitto
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  2. Elizabeth P. Crowe
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  3. Chad Lerner
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  4. Claudio Torres
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  5. Christian Sell
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Correspondence to Christian Sell .

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  1. Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA

    Eishi Noguchi

  2. Dept of Biochemistry & Molecular Biology, Drexel University College of Medicine, Philadelphia, USA

    Mariana C. Gadaleta

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Bitto, A., Crowe, E.P., Lerner, C., Torres, C., Sell, C. (2014). The Senescence Arrest Program and the Cell Cycle. In: Noguchi, E., Gadaleta, M. (eds) Cell Cycle Control. Methods in Molecular Biology, vol 1170. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0888-2_8

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  • DOI: https://doi.org/10.1007/978-1-4939-0888-2_8

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