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Interplay Between the Cell Cycle and Double-Strand Break Response in Mammalian Cells

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Book cover Cell Cycle Control

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1170))

Abstract

The cell cycle is intimately associated with the ability of cells to sense and respond to and repair DNA damage. Understanding how cell cycle progression, particularly DNA replication and cell division, are regulated and how DNA damage can affect these processes has been the subject of intense research. Recent evidence suggests that the repair of DNA damage is regulated by the cell cycle, and that cell cycle factors are closely associated with repair factors and participate in cellular decisions regarding how to respond to and repair damage. Precise regulation of cell cycle progression in the presence of DNA damage is essential to maintain genomic stability and avoid the accumulation of chromosomal aberrations that can promote tumor formation. In this review, we discuss the current understanding of how mammalian cells induce cell cycle checkpoints in response to DNA double-strand breaks. In addition, we discuss how cell cycle factors modulate DNA repair pathways to facilitate proper repair of DNA lesions.

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Acknowledgements

The authors are indebted to Oleg Alekseev for editing and to members of the Clifford and Noguchi laboratories for helpful discussions and to W.W. Smith Foundation and the PA Tobacco Settlement Funds for research support. We apologize to colleagues whose research we have failed to cite due to the breadth of the topics.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, 245 N 15th Street, MS 497, Philadelphia, PA, 19102, USA

    Kate Beishline & Jane Azizkhan-Clifford

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  1. Kate Beishline
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  2. Jane Azizkhan-Clifford
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Correspondence to Jane Azizkhan-Clifford .

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Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA

    Eishi Noguchi

  2. Dept of Biochemistry & Molecular Biology, Drexel University College of Medicine, Philadelphia, USA

    Mariana C. Gadaleta

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Beishline, K., Azizkhan-Clifford, J. (2014). Interplay Between the Cell Cycle and Double-Strand Break Response in Mammalian Cells. In: Noguchi, E., Gadaleta, M. (eds) Cell Cycle Control. Methods in Molecular Biology, vol 1170. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0888-2_3

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  • DOI: https://doi.org/10.1007/978-1-4939-0888-2_3

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-0887-5

  • Online ISBN: 978-1-4939-0888-2

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