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Use of Biguanides to Improve Response to Chemotherapy

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Cancer Cell Signaling

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1165))

Abstract

Metformin is a commonly utilized antidiabetic agent, which has been associated with improved clinical outcomes in cancer patients. The precise mechanism of action remains unclear, but preclinical evidence suggests that metformin can sensitize tumor cells to the effects to conventional chemotherapeutic agents and ionizing radiation (IR). In this chapter we discuss the general background of an approach to evaluate the effects of metformin on conventional chemotherapeutic agent toxicity in a preclinical model.

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Author information

Authors and Affiliations

  1. Bobby R. Alford Department of Otolaryngology—Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA

    Vlad C. Sandulache

  2. Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, 77030, USA

    Liangpeng Yang & Heath D. Skinner

Authors
  1. Vlad C. Sandulache
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  2. Liangpeng Yang
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  3. Heath D. Skinner
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Corresponding author

Correspondence to Heath D. Skinner .

Editor information

Editors and Affiliations

  1. Universidad Nacional AutĂłnoma de MĂ©xico, Mexico D.F., Mexico

    Martha Robles-Flores

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Sandulache, V.C., Yang, L., Skinner, H.D. (2014). Use of Biguanides to Improve Response to Chemotherapy. In: Robles-Flores, M. (eds) Cancer Cell Signaling. Methods in Molecular Biology, vol 1165. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0856-1_1

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  • DOI: https://doi.org/10.1007/978-1-4939-0856-1_1

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-0855-4

  • Online ISBN: 978-1-4939-0856-1

  • eBook Packages: Springer Protocols

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