Abstract
Osteoclasts are bone-resorbing cells that differentiate from the macrophage/monocyte lineage. The master transcription factor NFATc1 has a central role in the process of this differentiation. Thus, it is important to understand the NFATc1-centered transcription factor regulatory networks (TFRNs) in terms of the mechanisms of NFATc1 expression and activation as well as the gene expression regulated by NFATc1. The Genome Network Project has provided a unique opportunity for the analysis of NFATc1-centered TFRNs in osteoclasts. Here we introduce a report on the application of the methods established by the project for osteoclast biology and a summarization of the results obtained in this project thus far.
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Acknowledgement
This work was supported in part by a grant for Genome Network Project from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT), and a grant for ERATO, Takayanagi Osteonetwork Project from the Japan Science and Technology Agency (H. T.)
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Shinohara, M., Takayanagi, H. (2014). Analysis of NFATc1-Centered Transcription Factor Regulatory Networks in Osteoclast Formation. In: Miyamoto-Sato, E., Ohashi, H., Sasaki, H., Nishikawa, Ji., Yanagawa, H. (eds) Transcription Factor Regulatory Networks. Methods in Molecular Biology, vol 1164. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0805-9_14
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DOI: https://doi.org/10.1007/978-1-4939-0805-9_14
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