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Cerebral Monitoring and Surveillance Using High-Resolution Functional Optical Imaging

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Neurovascular Coupling Methods

Part of the book series: Neuromethods ((NM,volume 88))

Abstract

Near-infrared (NIR) optical techniques, using large-area sensing arrays that provide for transcranial measures of cortical function, are finding increasing use for functional assessment of brain activity. In this chapter, we review current capabilities of these methodologies and describe their application to an in vivo large animal model, Bonnet macaque, for the purpose of imaging hemodynamic responses to clinically significant events, including detection of cerebral ischemia and hemorrhage. The described methodology outlines the technology and method of high-density diffuse optical tomography (DOT), as explored using recently developed analysis resources whose accuracy is independently validated. Also discussed are solutions to commonly encountered problems related to data collection and analysis.

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Acknowledgements

This research was supported in part by the National Institutes of Health (NIH) under Grants nos. R21NS067278, R42NS050007, and 5R44NS049734; by Defense Advanced Research Projects Agency project N66001-10-C-2008; and by the Empire Clinical Research Investigator Program (ECRIP) of the New York State Department of Health.

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Authors and Affiliations

  1. Departments of Surgery and Neurology, Empire Clinical Research Investigator Program (ECRIP), State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, 11203, NY, USA

    Anthony D. Uglialoro

  2. NIRx Medical Technologies, LLC, Glen Head, 11545, NY, USA

    Harry L. Graber, Yong Xu & Sergio A. Ramirez

  3. Department of Pathology, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, MSC 25, Brooklyn, 11203, NY, USA

    Douglas S. Pfeil, Harry L. Graber, Yong Xu & Randall L. Barbour Ph.D.

  4. Department of Surgery, The Brooklyn Hospital Center, 121 Dekalb Avenue, Brooklyn, 11201, NY, USA

    Tigran Gevorgyan

  5. Departments of Radiology, Neurology, and Neurosurgery, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, 11203, NY, USA

    Sundeep Mangla

  6. Department of Neurology, and Physiology and Pharmacology, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, 11203, NY, USA

    Frank C. Barone

  7. Department of Pathology and Neurology, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, MSC 25, Brooklyn, 11203, NY, USA

    Jenny Libien

  8. Department of Anesthesiology, Yale School of Medicine, 333 Cedar Street, New Haven, 06520, CT, USA

    Jean Charchaflieh

  9. Department of Surgery, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, 11203, NY, USA

    John G. Kral, Sergio A. Ramirez & Daniel C. Lee

  10. Department of Surgery, Texas Tech University Health Science Center, 3601 4th Street, Lubbock, 79430, TX, USA

    LeRone Simpson

  11. Department of Medicine, Empire Clinical Research Investigator Program, Interfaith Medical Center, 1545 Atlantic Avenue, Brooklyn, 11213, NY, USA

    Daniel C. Lee

Authors
  1. Anthony D. Uglialoro
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  2. Douglas S. Pfeil
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  3. Tigran Gevorgyan
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  4. Harry L. Graber
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  5. Yong Xu
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  6. Sundeep Mangla
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  7. Frank C. Barone
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  8. Jenny Libien
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  9. Jean Charchaflieh
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  10. John G. Kral
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  11. Sergio A. Ramirez
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  12. LeRone Simpson
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  13. Daniel C. Lee
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  14. Randall L. Barbour Ph.D.
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Corresponding author

Correspondence to Randall L. Barbour Ph.D. .

Editor information

Editors and Affiliations

  1. Weill Cornell Medical College, New York, New York, USA

    Mingrui Zhao

  2. Weill Cornell Medical College, New York, New York, USA

    Hongtao Ma

  3. Weill Cornell Medical College, New York, New York, USA

    Theodore H. Schwartz

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Uglialoro, A.D. et al. (2014). Cerebral Monitoring and Surveillance Using High-Resolution Functional Optical Imaging. In: Zhao, M., Ma, H., Schwartz, T. (eds) Neurovascular Coupling Methods. Neuromethods, vol 88. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0724-3_16

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  • DOI: https://doi.org/10.1007/978-1-4939-0724-3_16

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  • Print ISBN: 978-1-4939-0723-6

  • Online ISBN: 978-1-4939-0724-3

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