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Cerebral Blood Flow Imaging with Laser Speckle Contrast Imaging

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Neurovascular Coupling Methods

Part of the book series: Neuromethods ((NM,volume 88))

Abstract

Laser speckle contrast imaging (LSCI) is a technique for dynamic visualization of blood flow on tissue surfaces. LSCI produces images of blood flow in real-time using very simple instrumentation without the need for exogenous contrast agents, and has been widely used both in pre-clinical studies of neurological disease as well as clinical applications for monitoring of perfusion. One of the limitations of LSCI is the challenge of obtaining quantitative blood flow information. An extension to LSCI called multi-exposure speckle imaging (MESI) overcomes some of these limitations and enables repeated blood flow measurements to be performed reliably. This chapter describes MESI imaging and the use of LSCI in humans during neurosurgery.

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Author information

Authors and Affiliations

  1. Department of Biomedical Engineering, The University of Texas at Austin, Biomedical Engineering Bldg (BME) Room 3.314, 107 W. Dean Keeton Street, Austin, TX, 78712, USA

    S. M. Shams Kazmi, Lisa M. Richards & Andrew K. Dunn

Authors
  1. S. M. Shams Kazmi
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  2. Lisa M. Richards
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  3. Andrew K. Dunn
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Corresponding author

Correspondence to Andrew K. Dunn .

Editor information

Editors and Affiliations

  1. Weill Cornell Medical College, New York, New York, USA

    Mingrui Zhao

  2. Weill Cornell Medical College, New York, New York, USA

    Hongtao Ma

  3. Weill Cornell Medical College, New York, New York, USA

    Theodore H. Schwartz

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Kazmi, S.M.S., Richards, L.M., Dunn, A.K. (2014). Cerebral Blood Flow Imaging with Laser Speckle Contrast Imaging. In: Zhao, M., Ma, H., Schwartz, T. (eds) Neurovascular Coupling Methods. Neuromethods, vol 88. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0724-3_15

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  • DOI: https://doi.org/10.1007/978-1-4939-0724-3_15

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-0723-6

  • Online ISBN: 978-1-4939-0724-3

  • eBook Packages: Springer Protocols

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