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Neurovascular Coupling in Relation to Cortical Spreading Depression

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Neurovascular Coupling Methods

Part of the book series: Neuromethods ((NM,volume 88))

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Abstract

Cortical spreading depression (SD) has been known for more than 70 years. It has been a unique method investigating basic neurophysiology. A growing body of evidence indicates SD is involved in clinical conditions such as migraine with aura, subarachnoid hemorrhage, and traumatic brain injury. In this chapter we describe the application of SD in studying neurovascular and neurometabolic coupling in rat cerebral cortex. Description of the different techniques (electrophysiology, laser-Doppler flowmetry, and oxygen-sensitive electrodes) is followed by in depth step-by-step instructions on how to use them. This chapter will also describe the vascular consequences of SD and how to elicit SD experimentally.

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Acknowledgements

This study was supported by the NORDEA Foundation/Center for Healthy Aging, the Lundbeck Foundation via the Lundbeck Foundation Center for Neurovascular Signaling (LUCENS), the NOVO-Nordisk Foundation, the Danish Medical Research Council, and Foundation Leducq.

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Authors and Affiliations

  1. Department of Clinical Neurophysiology, Glostrup Hospital, Nordre Ringvej 57, Glostrup, 2600, Denmark

    Henning Piilgaard & Martin Lauritzen

  2. Center for Healthy Aging and Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej 3B, Copenhagen, 2200, Denmark

    Martin Lauritzen

Authors
  1. Henning Piilgaard
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  2. Martin Lauritzen
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Corresponding author

Correspondence to Henning Piilgaard .

Editor information

Editors and Affiliations

  1. Weill Cornell Medical College, New York, New York, USA

    Mingrui Zhao

  2. Weill Cornell Medical College, New York, New York, USA

    Hongtao Ma

  3. Weill Cornell Medical College, New York, New York, USA

    Theodore H. Schwartz

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Piilgaard, H., Lauritzen, M. (2014). Neurovascular Coupling in Relation to Cortical Spreading Depression. In: Zhao, M., Ma, H., Schwartz, T. (eds) Neurovascular Coupling Methods. Neuromethods, vol 88. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0724-3_14

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  • DOI: https://doi.org/10.1007/978-1-4939-0724-3_14

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-0723-6

  • Online ISBN: 978-1-4939-0724-3

  • eBook Packages: Springer Protocols

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