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In Vitro Maturation of Immature Human Oocytes for Clinical Application

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Human Fertility

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1154))

Abstract

Meiotic progression in the oocyte is defined as oocyte maturation from reinitiation of the first meiotic division from the germinal vesicle (GV) stage to the metaphase-II (M-II) stage (Fig. 1), (Cha and Chian, Hum Reprod Update 4:103–120, 1998). Priming with FSH or HCG prior to immature oocyte retrieval improves oocyte maturation and pregnancy rates. The size of follicles may be an important feature for IVM treatment. The combination of natural-cycle IVF with immature oocyte retrieval followed by IVM is an attractive treatment for young women with all types of infertility without recourse to ovarian stimulation with an acceptable pregnancy rate.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, McGill University, Royal Victoria Hospital, Women’s Pavilion F3, 687 Pine Avenue West, Montreal, Quebec, Canada, H3A 1A1

    Ri-Cheng Chian

  2. Department of Obstetrics and Gynecology, Center for Reproductive Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, People’s Republic of China

    Yun-Xia Cao

Authors
  1. Ri-Cheng Chian
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  2. Yun-Xia Cao
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Correspondence to Ri-Cheng Chian .

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Editors and Affiliations

  1. The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York, USA

    Zev Rosenwaks

  2. Dept. Developmental & Regenerative Biology, Ichan School of Medicine at Mount Sinai, New York, New York, USA

    Paul M. Wassarman

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Chian, RC., Cao, YX. (2014). In Vitro Maturation of Immature Human Oocytes for Clinical Application. In: Rosenwaks, Z., Wassarman, P. (eds) Human Fertility. Methods in Molecular Biology, vol 1154. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0659-8_12

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  • DOI: https://doi.org/10.1007/978-1-4939-0659-8_12

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