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Human Fertility pp 251–260Cite as

Luteal Phase Support in ART Treatments

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1154))

Abstract

In a normal spontaneous menstrual cycle, the luteal phase is characterized by the production and secretion of estradiol (E) and progesterone (P) from the corpus luteum (CL) in an episodic manner. The steroidogenesis of the CL is dependent on continued tonic luteinizing hormone (LH) secretion (Fritz and Speroff, Clinical gynecologic endocrinology and infertility, 8th edn. Wolters Kluwer, Lippincott Williams & Wilkins, Philadelphia, 2011). The dependence of the CL was further supported by the prompt luteolysis that followed the administration of GnRH analogues or withdrawal of GnRH when ovulation has been induced by the administration of pulsatile GnRH (Hutchison and Zeleznik, Endocrinology 115:1780–1786, 1984; Fraser et al., Hum Reprod 12:430–435, 1997). Progesterone concentrations normally rise sharply after ovulation, reaching a peak approximately 8 days after the LH surge. Since the secretion of E and P during the luteal phase is episodic and correlates closely with LH pulses, relatively low mid-luteal progesterone levels can be found in the course of a totally normal luteal phase (Fritz and Speroff, Clinical gynecologic endocrinology and infertility, 8th edn. Wolters Kluwer, Lippincott Williams & Wilkins, Philadelphia, 2011).

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Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Israel

    Yuval Or M.D., Edi Vaisbuch M.D. & Zeev Shoham M.D.

  2. Hebrew University of Jerusalem and Hadassah School of Medicine, Jerusalem, Israel

    Yuval Or M.D., Edi Vaisbuch M.D. & Zeev Shoham M.D.

Authors
  1. Yuval Or M.D.
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  2. Edi Vaisbuch M.D.
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  3. Zeev Shoham M.D.
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Corresponding author

Correspondence to Zeev Shoham M.D. .

Editor information

Editors and Affiliations

  1. The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York, USA

    Zev Rosenwaks

  2. Dept. Developmental & Regenerative Biology, Ichan School of Medicine at Mount Sinai, New York, New York, USA

    Paul M. Wassarman

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Or, Y., Vaisbuch, E., Shoham, Z. (2014). Luteal Phase Support in ART Treatments. In: Rosenwaks, Z., Wassarman, P. (eds) Human Fertility. Methods in Molecular Biology, vol 1154. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0659-8_10

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  • DOI: https://doi.org/10.1007/978-1-4939-0659-8_10

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-0658-1

  • Online ISBN: 978-1-4939-0659-8

  • eBook Packages: Springer Protocols

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