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Engineering and Analyzing Multicellular Systems pp 3–25Cite as

Recent Progress in Engineering Human-Associated Microbiomes

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1151))

Abstract

Recent progress in molecular biology and genetics opens up the possibility of engineering a variety of biological systems, from single-cellular to multicellular organisms. The consortia of microbes that reside on the human body, the human-associated microbiota, are particularly interesting as targets for forward engineering and manipulation due to their relevance in health and disease. New technologies in analysis and perturbation of the human microbiota will lead to better diagnostic and therapeutic strategies against diseases of microbial origin or pathogenesis. Here, we discuss recent advances that are bringing us closer to realizing the true potential of an engineered human-associated microbial community.

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Acknowledgements

H.H.W. acknowledges the generous support from the National Institutes of Health Director’s Early Independence Award (grant 1DP5OD009172-01). S.J.Y. acknowledges support from the National Science Foundation Graduate Research Fellowship and the MIT Neurometrix Presidential Graduate Fellowship. G.M.C. acknowledges support from the Department of Energy Genomes to Life Center (Grant DE-FG02-02ER63445).

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Authors and Affiliations

  1. Program in Medical Engineering Medical Physics, Harvard-MIT Health Sciences and Technology, Cambridge, MA, USA

    Stephanie J. Yaung

  2. Department of Genetics, Harvard Medical School, Boston, MA, USA

    Stephanie J. Yaung & George M. Church

  3. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA

    Stephanie J. Yaung & George M. Church

  4. Department of Systems Biology, Columbia University Medical Center, 701 W 168 Street, New York, NY, 10032, USA

    Harris H. Wang

  5. Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA

    Harris H. Wang

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  1. Stephanie J. Yaung
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  2. George M. Church
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  3. Harris H. Wang
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Correspondence to Harris H. Wang .

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  1. School of Life Sciences, University of Science & Technology of China,, Hefei, Anhui, China

    Lianhong Sun

  2. Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

    Wenying Shou

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Yaung, S.J., Church, G.M., Wang, H.H. (2014). Recent Progress in Engineering Human-Associated Microbiomes. In: Sun, L., Shou, W. (eds) Engineering and Analyzing Multicellular Systems. Methods in Molecular Biology, vol 1151. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0554-6_1

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