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Natural Riboflavin Analogs

  • Danielle Biscaro Pedrolli
  • Frank Jankowitsch
  • Julia Schwarz
  • Simone Langer
  • Shinobu Nakanishi
  • Matthias MackEmail author
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1146)

Abstract

Riboflavin analogs have a good potential to serve as basic structures for the development of novel anti-infectives. Riboflavin analogs have multiple cellular targets, since riboflavin (as a precursor to flavin cofactors) is active at more than one site in the cell. As a result, the frequency of developing resistance to antimicrobials based on riboflavin analogs is expected to be significantly lower. The only known natural riboflavin analog with antibiotic function is roseoflavin from the bacterium Streptomyces davawensis. This antibiotic negatively affects flavoenzymes and FMN riboswitches. Another roseoflavin producer, Streptomyces cinnabarinus, was recently identified. Possibly, flavin analogs with antibiotic activity are more widespread than anticipated. The same could be true for flavin analogs yet to be discovered, which could constitute tools for cellular chemistry, thus allowing a further extension of the catalytic spectrum of flavoenzymes.

Key words

Riboflavin analogs Antibiotics Roseoflavin Flavoenzymes FMN riboswitches 

Notes

Acknowledgments

This work was funded by the German “Federal Ministry of Education and Research” (BMBF) (FKZ 17PNT006) (“Qualifizierungs-/Profilierungsgruppe neue Technologien“) and the research training group NANOKAT (FKZ 0316052A) of the BMBF.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Danielle Biscaro Pedrolli
    • 1
  • Frank Jankowitsch
    • 1
  • Julia Schwarz
    • 1
  • Simone Langer
    • 1
  • Shinobu Nakanishi
    • 1
  • Matthias Mack
    • 1
    Email author
  1. 1.Institute for Technical Microbiology, Mannheim University of Applied SciencesMannheimGermany

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