Abstract
With the implementation of gene therapy looming in the near term, an effective delivery system using noninvasive, nonviral-mediated methods appears as an attractive option. This novel platform technology uses gas-filled, ultrasound-directed acoustic microspheres for both diagnostic imaging and therapy and yet may provide a key component for future success in the pursuit of single-gene replacement therapy.
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Acknowledgements
The authors would like to thank all members of the team who have made microbubble gene delivery a success in our lab. This includes physicist Kirk Wallace, ultrasound engineer David Mills, Chemists Matthew Butts, Bruce Johnson, and Binil Kandapallil, biologists Mike Marino, Chris Morton, Jeannette Roberts and Andrew Torres as well as the leadership team who make it possible.
The project described was supported in part under NIH SBIR 1R44HL095238 “Development of Novel Tissue Directed Ultrasound Therapeutic Gene Delivery System” from DHHS, National Heart, Lung and Blood Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of DHHS, NIH, National Heart, Lung and Blood Institute as well as funds from GE Global Research, Niskayuna NY.
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Castle, J., Feinstein, S.B. (2014). Ultrasound-Directed, Site-Specific Gene Delivery. In: Jain, K. (eds) Drug Delivery System. Methods in Molecular Biology, vol 1141. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0363-4_3
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DOI: https://doi.org/10.1007/978-1-4939-0363-4_3
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