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Drug Delivery System pp 165–184Cite as

Applications of Chitosan Nanoparticles in Drug Delivery

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1141))

Abstract

We have reviewed the binding affinities of several antitumor drugs doxorubicin (Dox), N-(trifluoroacetyl) doxorubicin (FDox), tamoxifen (Tam), 4-hydroxytamoxifen (4-Hydroxytam), and endoxifen (Endox) with chitosan nanoparticles of different sizes (chitosan-15, chitosan-100, and chitosan-200 KD) in order to evaluate the efficacy of chitosan nanocarriers in drug delivery systems. Spectroscopic and molecular modeling studies showed the binding sites and the stability of drug–polymer complexes. Drug–chitosan complexation occurred via hydrophobic and hydrophilic contacts as well as H-bonding network. Chitosan-100 KD was the more effective drug carrier than the chitosan-15 and chitosan-200 KD.

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Abbreviations

Ch:

Chitosan

Dox:

Doxorubicin

FDox:

N-(trifluoroacetyl) doxorubicin

Tam:

Tamoxifen

4-Hydroxytam:

4-Hydroxytamoxifen

Endox:

Endoxifen

PEG:

Poly(ethylene glycol)

FTIR:

Fourier transform infrared

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Acknowledgments

The financial support of the Natural Sciences and Engineering Research Council of Canada (NSERC) is highly appreciated.

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Authors and Affiliations

  1. Department of Chemistry–Physics, University of Québec at Trois-Rivières, Trois-Rivières, QC, Canada

    H. A. Tajmir-Riahi, S. Sanyakamdhorn, D. Agudelo & P. Chanphai

  2. Department of Chemistry, San Jose State University, San Jose, CA, USA

    Sh. Nafisi

Authors
  1. H. A. Tajmir-Riahi
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  2. Sh. Nafisi
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  3. S. Sanyakamdhorn
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  4. D. Agudelo
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  5. P. Chanphai
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Editor information

Editors and Affiliations

  1. Jain PharmaBiotech, Basel, Switzerland

    Kewal K. Jain

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Tajmir-Riahi, H.A., Nafisi, S., Sanyakamdhorn, S., Agudelo, D., Chanphai, P. (2014). Applications of Chitosan Nanoparticles in Drug Delivery. In: Jain, K. (eds) Drug Delivery System. Methods in Molecular Biology, vol 1141. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0363-4_11

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  • DOI: https://doi.org/10.1007/978-1-4939-0363-4_11

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