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Induced Murine Models of Systemic Lupus Erythematosus

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Systemic Lupus Erythematosus

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1134))

Abstract

Induced mouse models of systemic lupus erythematosus (SLE) have been developed to complement the spontaneous models. This chapter describes the methods used in the pristane-induced model and the chronic graft-versus-host disease (cGVHD) model, both of which have been extensively used. We will also outline the specific mechanisms of systemic autoimmunity that can be best characterized using each of these models.

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Author information

Authors and Affiliations

  1. Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL, USA

    Yuan Xu & Westley H. Reeves

  2. Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA

    Leilani Zeumer

  3. Department of Pathology, Immunology & Laboratory Medicine, University of Florida, Gainesville, FL, USA

    Laurence Morel

Authors
  1. Yuan Xu
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  2. Leilani Zeumer
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  3. Westley H. Reeves
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  4. Laurence Morel
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Editor information

Editors and Affiliations

  1. University of Exeter Medical School, Devon, United Kingdom

    Paul Eggleton

  2. Section of Immunology and Infection, Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom

    Frank J. Ward

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Xu, Y., Zeumer, L., Reeves, W.H., Morel, L. (2014). Induced Murine Models of Systemic Lupus Erythematosus. In: Eggleton, P., Ward, F. (eds) Systemic Lupus Erythematosus. Methods in Molecular Biology, vol 1134. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0326-9_9

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  • DOI: https://doi.org/10.1007/978-1-4939-0326-9_9

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-0325-2

  • Online ISBN: 978-1-4939-0326-9

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