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Nrf2-Target Approaches in Cancer Chemoprevention Mediated by Dietary Phytochemicals

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Book cover Cancer Prevention

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

Abstract

Cancer chemoprevention with natural phytochemical compounds is an emerging strategy to prevent, impede, delay, or cure cancer. This chapter reviews the basic methods used to study the cancer chemopreventive potential of dietary phytochemicals acting by activating the transcriptional factor, nuclear factor-erythroid 2-related factor 2 (Nrf2 or NFE2L2), a basic-region leucine zipper (bZIP) transcription factor that regulates the expression of many phase II detoxifying/antioxidant enzymes. The Nrf2-target approaches in cancer chemoprevention comprise different methods including examining the Nrf2 signaling pathway, Nrf2-deficient tumor mouse models, pharmacokinetics (PK)/pharmacodynamics (PD) assessment, and epigenetic regulation.

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Authors and Affiliations

  1. Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA

    Francisco Fuentes

  2. Department of Desert Agriculture and Biotechnology, Arturo Prat University, Iquique, Chile

    Francisco Fuentes

  3. Department of Pharmaceutics, Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA

    Limin Shu, Jong Hun Lee, Zheng-Yuan Su, Kyeong-Ryoon Lee & Ah-Ng Tony Kong

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  1. Francisco Fuentes
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  2. Limin Shu
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  3. Jong Hun Lee
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  4. Zheng-Yuan Su
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  5. Kyeong-Ryoon Lee
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  6. Ah-Ng Tony Kong
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Editors and Affiliations

  1. The Hormel Institute, Austin, Minnesota, USA

    Ann M. Bode

  2. The Hormel Institute, Austin, Minnesota, USA

    Zigang Dong

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Fuentes, F., Shu, L., Lee, J.H., Su, ZY., Lee, KR., Kong, AN.T. (2014). Nrf2-Target Approaches in Cancer Chemoprevention Mediated by Dietary Phytochemicals. In: Bode, A., Dong, Z. (eds) Cancer Prevention. Methods in Pharmacology and Toxicology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-9227-6_3

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  • DOI: https://doi.org/10.1007/978-1-4614-9227-6_3

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