Mitochondria are one of intracellular organelles acting as the main energy providers of the cell. Increasing evidences have demonstrated that mitochondrial dysfunctions in respiratory chain function, oxidative stress, dynamics (shape, size, fission-fusion, distribution, movement, etc.), calcium-handling capacities, and protein mutation play a central pathogenic role in neurodegenerative diseases such as Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and Alzheimer’s disease. Protocols developed for the isolation of pure and intact mitochondria will contribute considerably to the understanding of the pathogenic mechanisms of neurodegenerative disorders.
Mitochondria Brain tissues Isolation Reactive oxygen species Neurodegenerative disorders
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