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Neuronanomedicine

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Current Laboratory Methods in Neuroscience Research

Part of the book series: Springer Protocols Handbooks ((SPH))

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Abstract

The need for the development of nanomedicines for the treatment of human immunodeficiency viral (HIV) infections is urgent and immediate. To this end, our laboratories have devised the means to utilize mononuclear phagocytes as nanoparticle carriers. Drug nanocarriers are specifically relevant to the central nervous system as they can target sites of inflammation including those contained within a diseased brain and enhance therapeutic efficacy. Nonetheless and despite the promise for HIV infections, nanomedicines have yet to make their mark. This, we posit, will change as translation of nanoformulation technology for clinical therapeutic applications shows its complete potential. This chapter reviews the promise of this technology and outlines in clear form the methods for manufacturing and testing the particles. Such works will have broad applicability beyond viral infections of the nervous system and are particularly relevant for this book series.

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Author information

Authors and Affiliations

  1. Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 985800 Nebraska Medical Center, Omaha, NE, USA

    JoEllyn M. McMillan Ph.D

  2. Department of Pharmacology and Experimental Neuroscience and Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha, NE, USA

    Xin-Ming Liu & Howard E. Gendelman M.D.

  3. Department of Pharmaceutical Sciences, and Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha, NE, USA

    Xin-Ming Liu & Howard E. Gendelman M.D.

Authors
  1. JoEllyn M. McMillan Ph.D
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  2. Xin-Ming Liu
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  3. Howard E. Gendelman M.D.
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Corresponding author

Correspondence to Howard E. Gendelman M.D. .

Editor information

Editors and Affiliations

  1. Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA

    Huangui Xiong  & Howard E. Gendelman  & 

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McMillan, J.M., Liu, XM., Gendelman, H.E. (2014). Neuronanomedicine. In: Xiong, H., Gendelman, H.E. (eds) Current Laboratory Methods in Neuroscience Research. Springer Protocols Handbooks. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8794-4_17

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  • DOI: https://doi.org/10.1007/978-1-4614-8794-4_17

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-8793-7

  • Online ISBN: 978-1-4614-8794-4

  • eBook Packages: Springer Protocols

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