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Quantum Dots pp 199–212Cite as

Stimulus-Sensitive Theranostic Delivery Systems Based on Microcapsules Encoded with Quantum Dots and Magnetic Nanoparticles

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 2135))

Abstract

Fluorescent semiconductor nanocrystals, known as quantum dots (QDs), and magnetic nanoparticles (MNPs) are extensively studied perspective tools for optical (fluorescence) and magnetic resonance imaging techniques. The unique optical properties, high photostability, and bright luminescence of QDs make them more promising fluorophores than the classical organic dyes. Encoding polyelectrolyte microcapsules with QDs and MNPs ensures their sensitivity to both photoexcitation and magnetic field. This chapter presents the protocol for obtaining a stimulus-sensitive delivery system based on QD- and MNP-encoded polyelectrolyte microcapsules by means of layer-by-layer self-assembly. The resultant fluorescent magnetic polyelectrolyte microcapsules are 3.4–5.5 μm in size, have a hollow structure, and are brightly fluorescent to be detected with the standard imaging equipment. Polyelectrolyte microcapsule surface bears functional groups for subsequent functionalization with vector capture molecules. The polyelectrolyte microcapsules containing combination of QDs and MNPs are advanced visualization tools, since they can be sorted in a magnetic field and at the same time are suitable for fluorescent imaging what can be applied within a wide range of diagnostic and therapeutic protocols.

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Acknowledgments

This study was supported by the Ministry of Education and Science of the Russian Federation, State Contract no. 16.1034.2017/ΠЧ.

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Authors and Affiliations

  1. Laboratory of Nano-bioengineering, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, Russian Federation

    Galina Nifontova & Igor Nabiev

  2. Translational Molecular Imaging, Max-Planck-Institute of Experimental Medicine, Göttingen, Germany

    Fernanda Ramos-Gomes & Frauke Alves

  3. Clinic of Haematology and Medical Oncology, University Medical Center Göttingen, Göttingen, Germany

    Frauke Alves

  4. Laboratoire de Recherche en Nanosciences, LRN-EA4682, Université de Reims Champagne-Ardenne, Reims, France

    Igor Nabiev & Alyona Sukhanova

Authors
  1. Galina Nifontova
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  2. Fernanda Ramos-Gomes
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  3. Frauke Alves
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  4. Igor Nabiev
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  5. Alyona Sukhanova
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Corresponding authors

Correspondence to Igor Nabiev or Alyona Sukhanova .

Editor information

Editors and Affiliations

  1. Biomedical Nanotechnology Group, Federal University of Pernambuco, Recife, Pernambuco, Brazil

    Adriana Fontes

  2. Biomedical Nanotechnology Group, Federal University of Pernambuco, Recife, Pernambuco, Brazil

    Beate S. Santos

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Nifontova, G., Ramos-Gomes, F., Alves, F., Nabiev, I., Sukhanova, A. (2020). Stimulus-Sensitive Theranostic Delivery Systems Based on Microcapsules Encoded with Quantum Dots and Magnetic Nanoparticles. In: Fontes, A., Santos, B. (eds) Quantum Dots. Methods in Molecular Biology, vol 2135. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0463-2_11

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  • DOI: https://doi.org/10.1007/978-1-0716-0463-2_11

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0462-5

  • Online ISBN: 978-1-0716-0463-2

  • eBook Packages: Springer Protocols

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