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Antigenic Cartography: Overview and Current Developments

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Animal Influenza Virus

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2123))

Abstract

Antigenic cartography is a powerful method that allows for the calculation of antigenic distances between influenza viruses or sera and their positioning on a map, by quantifying raw data from hemagglutination inhibition assays. As a consequence, the antigenic drift of influenza viruses over time can be visualized in a straightforward manner. Antigenic cartography is not only useful in the research of influenza virus evolution but also in the surveillance of influenza viruses. Most importantly, antigenic cartography plays a very important role in vaccine updating decisions, since by calculating the antigenic distances between a vaccine strain and circulating strains, an informed decision can be made on whether the distances are large enough to warrant a vaccine update or not. Recent improvements in antigenic cartography calculations have significantly improved its accuracy.

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Author information

Authors and Affiliations

  1. Exotic and Emerging Avian Viral Diseases Unit, US National Poultry Research Center, US Department of Agriculture, Agricultural Research Service, Athens, GA, USA

    Ioannis Sitaras

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  1. Ioannis Sitaras
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Editors and Affiliations

  1. Exotic and Emerging Avian Viral Diseases Unit, US National Poultry Research Center, US Department of Agriculture, Agricultural Research Service, Athens, GA, USA

    Erica Spackman

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Sitaras, I. (2020). Antigenic Cartography: Overview and Current Developments. In: Spackman, E. (eds) Animal Influenza Virus. Methods in Molecular Biology, vol 2123. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0346-8_5

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  • DOI: https://doi.org/10.1007/978-1-0716-0346-8_5

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0345-1

  • Online ISBN: 978-1-0716-0346-8

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