Abstract
The unique combination of microwave heating with optimized carbodiimide activation has proven to be an indispensable technique for high-throughput peptide production. Here, we describe new methods in microwave-assisted solid phase peptide synthesis and optimized post-synthesis modifications that have been recently developed. These methods have drastically reduced synthesis time and solvent requirement while delivering peptides in high crude purities.
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References
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US Patent: US 9,969,769
US Application 20180066013
US 10,239,914
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Singh, S.K., Collins, J.M. (2020). New Developments in Microwave–Assisted Solid Phase Peptide Synthesis. In: Hussein, W., Skwarczynski, M., Toth, I. (eds) Peptide Synthesis. Methods in Molecular Biology, vol 2103. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0227-0_6
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DOI: https://doi.org/10.1007/978-1-0716-0227-0_6
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Publisher Name: Humana, New York, NY
Print ISBN: 978-1-0716-0226-3
Online ISBN: 978-1-0716-0227-0
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