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Quantitative Trait Loci (QTL) Mapping

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eQTL Analysis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2082))

Abstract

Quantitative trait loci (QTL) are genetic regions that influence phenotypic variation of a complex trait, often through genetic interactions with each other and the environment. These are commonly identified through a statistical genetic analysis known as QTL mapping. Here, I present a step-by-step, practical approach to QTL mapping along with a sample data file. I focus on methods commonly used and discoveries that have been made in fishes, and utilize a multiple QTL mapping (MQM) approach in the free software package R/qtl.

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Authors and Affiliations

  1. Department of Biological Sciences, Clemson University, Clemson, SC, USA

    Kara E. Powder

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  1. Kara E. Powder
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Correspondence to Kara E. Powder .

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  1. Temple University, Philadelphia, PA, USA

    Xinghua Mindy Shi

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Powder, K.E. (2020). Quantitative Trait Loci (QTL) Mapping. In: Shi, X. (eds) eQTL Analysis. Methods in Molecular Biology, vol 2082. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0026-9_15

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  • DOI: https://doi.org/10.1007/978-1-0716-0026-9_15

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0025-2

  • Online ISBN: 978-1-0716-0026-9

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