Brain-Derived Neurotrophic Factor and the Attività plastica dei neuroni: The Neuronal Plasticity as Defined by Ernesto Lugaro (1870–1940)
Many brain functions frequently change across a life span in response to new experience, the rewiring of neural circuits, homeostatic factors, and environmental events. Extracellular signals can promote rapid responses in gene expression and protein synthesis that trigger growth and plasticity in the nervous system. A key component is activity-dependent events and their participation in synaptic function. These responses are required for long-lasting effects in synaptic plasticity associated with learning and memory. The neurotrophin brain-derived neurotrophic factor (BDNF), discovered in 1982, is well established as a prominent molecule responsible for inducing synaptogenesis, dendritic growth, and long-term potentiation. This volume of the Neuromethods Series is dedicated to the methods that have allowed to study the many potential mechanisms whereby BDNF signaling accounts for its many physiological effects.
KeywordsBDNF Neurotrophins Synaptic plasticity
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