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Quantification of Cerebral Blood Flow

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Molecular Imaging in the Clinical Neurosciences

Part of the book series: Neuromethods ((NM,volume 71))

Abstract

Regional cerebral blood flow (CBF) can be quantified using oxygen-15-labelled water ([15O]H2O) and positron emission tomography. In this overview, first a description is given of the early methods developed for the first generation of PET scanners in which the volume of distribution of water (V T) had to be fixed. Next, the tracer kinetic model for [15O]H2O is presented, and it is shown that both CBF and V T can be obtained using dynamic scanning and non-linear regression. Finally, several practical issues are discussed and guidelines are given for obtaining accurate CBF measurements.

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Author information

Authors and Affiliations

  1. Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands

    Adriaan A. Lammertsma

Authors
  1. Adriaan A. Lammertsma
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Editor information

Editors and Affiliations

  1. , Dept. of Psychiatry, Psychotherapy,, RWTH Aachen University, Pauwelsstr. 30, Aachen, 52074, Germany

    Gerhard Gründer

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© 2012 Springer Science+Business Media New York

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Lammertsma, A.A. (2012). Quantification of Cerebral Blood Flow. In: Gründer, G. (eds) Molecular Imaging in the Clinical Neurosciences. Neuromethods, vol 71. Humana Press, Totowa, NJ. https://doi.org/10.1007/7657_2012_43

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  • DOI: https://doi.org/10.1007/7657_2012_43

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61779-988-4

  • Online ISBN: 978-1-61779-989-1

  • eBook Packages: Springer Protocols

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