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Integrin Targeting Systems for Tumor Diagnosis and Therapy pp 123–134Cite as

Integrin αvβ3-Targeted Optical Imaging with Metal Oxide Nanomaterials: Focusing on Zinc Oxide

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Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

Abstract

Integrin αvβ3 is one of the most important factors during angiogenesis (i.e., the formation of new vasculature). To fully elucidate its role in different pathological process, a tool which can visualize its distribution profile and/or fluctuation will be of great value. Metal oxide nanomaterials, with unique physical properties and versatile biological applications, can be suitable candidates for this type of application. Among all the metal oxide nanomaterials, zinc oxide (ZnO) has different forms of nanostructures and possesses several distinct advantages including tunable luminescence, good biocompatibility, low cytotoxicity, and versatile chemical reaction capacity with different molecules. Based on all these properties, ZnO nanomaterials can serve as a useful platform especially as an imaging tool for studying integrin αvβ3 in cells. With further optimization, these ZnO nanomaterials can be attractive alternatives for image-guided drug delivery applications via integrin αvβ3-mediated pathways. This chapter provides detailed protocols of how to produce luminescent ZnO nanomaterials (e.g., nanowires or nanoparticles) and use them at the cellular level for optical imaging of integrin αvβ3.

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Author information

Authors and Affiliations

  1. Department of Radiology, University of Michigan Health Systems, Ann Arbor, MI, 48109-2200, USA

    Hao Hong

  2. Department of Radiology and Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Room 7137, 1111 Highland Ave, Madison, WI, 53705-2275, USA

    Weibo Cai

  3. University of Wisconsin Carbone Cancer Center, Madison, WI, 53705-2275, USA

    Weibo Cai

Authors
  1. Hao Hong
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  2. Weibo Cai
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Corresponding author

Correspondence to Weibo Cai .

Editor information

Editors and Affiliations

  1. Department of Gastroenterology and Hepatology, UniversitätsSpital Zürich, Zürich, Switzerland

    Eleonora Patsenker

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Hong, H., Cai, W. (2015). Integrin αvβ3-Targeted Optical Imaging with Metal Oxide Nanomaterials: Focusing on Zinc Oxide. In: Patsenker, E. (eds) Integrin Targeting Systems for Tumor Diagnosis and Therapy. Methods in Pharmacology and Toxicology. Humana Press, New York, NY. https://doi.org/10.1007/7653_2015_60

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  • DOI: https://doi.org/10.1007/7653_2015_60

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7443-6

  • Online ISBN: 978-1-4939-7445-0

  • eBook Packages: Springer Protocols

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