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Histopathology in Mouse Models of Rheumatoid Arthritis

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Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

Abstract

Murine models of rheumatoid arthritis are widely used for mechanistic studies and for the validation of therapeutic targets. Many models exist and can be classified into induced and spontaneous types. Even though models vary considerably in the pathogenesis of lesions, overlapping spectra of morphological features render the commonly used models suitable for standard histopathological examination and scoring strategies.

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Authors and Affiliations

  1. Department of Research Pathology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA

    Patrick Caplazi & Lauri Diehl

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  1. Patrick Caplazi
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  2. Lauri Diehl
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Correspondence to Patrick Caplazi .

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  1. Flagship Biosciences, LLC, Westminster, Colorado, USA

    Steven J. Potts

  2. University of North Carolina, Chapel Hill, North Carolina, USA

    David A. Eberhard

  3. Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA

    Keith A. Wharton, Jr.

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Caplazi, P., Diehl, L. (2014). Histopathology in Mouse Models of Rheumatoid Arthritis. In: Potts, S., Eberhard, D., Wharton, Jr., K. (eds) Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development. Methods in Pharmacology and Toxicology. Humana Press, New York, NY. https://doi.org/10.1007/7653_2014_20

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  • DOI: https://doi.org/10.1007/7653_2014_20

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  • Print ISBN: 978-1-4939-2680-0

  • Online ISBN: 978-1-4939-2681-7

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