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Stem Cell Nanotechnology pp 119–128Cite as

Fabrication and Electrospinning of 3D Biodegradable Poly-l-Lactic Acid (PLLA) Nanofibers for Clinical Application

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 2125))

Abstract

Poly-l-lactic acid (PLLA) is a biodegradable synthetic polyester synthesized by polymerization or polycondensation. PLLA hydrolytically degrades into lactic acid, a biocompatible metabolic by-product, making it suitable for clinical applications. PLLA scaffolds or nanofibers have been used in various regenerative medicine and drug delivery applications. These scaffolds impart biocompatible properties of high surface area, hydrophobicity, native extracellular properties, and mechanical strength for an organ system. Moreover, PLLA nanofibers hold great promise as drug delivery systems, where fabrication parameters and drug-PLA compatibility greatly affect the drug release kinetics. In this chapter, we present the protocols to fabricate, electrospinning, and validation of 3D PLLA nanofibrous scaffolds for tissue engineering application and offer perspectives on their future use.

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Acknowledgments

We would like to thank our technicians from Frontier Mediville Mrs. Lavanya Rajasekaran and Mrs. Vimala Amulraj who helped us with the protocols and evaluation of electrospun nanofibers.

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Authors and Affiliations

  1. Dr. K.M. Cherian Heart Foundation, Chennai, India

    Balasundari Ramesh & Kotturathu Mammen Cherian

  2. University of Medicine and Health Sciences, Basseterre, St. Kitts and Nevis, West Indies, Trinidad

    Adegbenro Omotuyi John Fakoya

Authors
  1. Balasundari Ramesh
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  2. Kotturathu Mammen Cherian
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  3. Adegbenro Omotuyi John Fakoya
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Editor information

Editors and Affiliations

  1. Ottawa, ON, Canada

    Kursad Turksen

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Ramesh, B., Cherian, K.M., Fakoya, A.O.J. (2019). Fabrication and Electrospinning of 3D Biodegradable Poly-l-Lactic Acid (PLLA) Nanofibers for Clinical Application. In: Turksen, K. (eds) Stem Cell Nanotechnology. Methods in Molecular Biology, vol 2125. Humana, New York, NY. https://doi.org/10.1007/7651_2019_213

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  • DOI: https://doi.org/10.1007/7651_2019_213

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0359-8

  • Online ISBN: 978-1-0716-0360-4

  • eBook Packages: Springer Protocols

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